- Case Report
- Immunology
- Concomitant use of corticosteroid and antimicrobials for liver abscesses in patients with chronic granulomatous disease
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Kyung-Sue Shin, Mu Suk Lee
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Clin Exp Pediatr. 2016;59(4):196-201. Published online April 30, 2016
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Chronic granulomatous disease (CGD) is a rare inherited disorder caused by defective nicotinamide adenine dinucleotide phosphate oxidase enzyme and characterized by recurrent bacterial and fungal infections. Although liver abscess is a common manifestation of CGD, its management in CGD patients is not well-defined. In addition, the generalized guidelines for treating liver abscesses do not necessarily apply to CGD patients. Corticosteroids... |
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- Original Article
- Long-term outcome of patients with p22phox-deficient chronic granulomatous disease on Jeju Island, Korea
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Hyun Sik Kang, Geol Hwang, Kyung-Sue Shin
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Clin Exp Pediatr. 2015;58(4):129-135. Published online April 22, 2015
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Purpose This study investigated the long-term clinical outcomes of patients with p22phox-deficient chronic granulomatous disease (CGD) on Jeju Island and retrospectively evaluated the effects of interferon-gamma (IFN-γ) prophylaxis. MethodsThe medical records of 15 patients with CGD were retrospectively reviewed. The efficacy of IFN-γ prophylaxis was evaluated by comparing the frequency of severe infections before and after starting continuous prophylaxis with IFN-γ. ResultsAt the... |
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- Toll-like receptor 2 expression on monocytes from patients with BCG vaccine-associated suppurative lymphadenitis
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Hyun Joo Oh, Kyung-Sue Shin
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Clin Exp Pediatr. 2009;52(6):667-673. Published online June 15, 2009
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Purpose : Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacterial infections. The purpose of this study was to analyze TLR2 surface expressions and TLR2-mediated tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) production in patients with BCG vaccine-associated suppurative lymphadenitis.
Methods : Peripheral monocytes were separated from 16 patients with BCG vaccine-associated suppurative lymphadenitis and 10 healthy... |
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- Case Report
- Familial systemic lupus erythematosus in two Korean male siblings
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Hyun Sik Kang, Hyun Ju Oh, Young Ree Kim, Jae-Wang Kim, Kyung-Sue Shin
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Clin Exp Pediatr. 2009;52(5):611-614. Published online May 15, 2009
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Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterized by the production of a wide range of autoantibodies, resulting in tissue damage. Although the susceptibility to SLE has been attributed to complex interactions between genetic and environmental factors, the influence of a genetic predisposition to SLE is supported by observations of familial aggregations. Family studies have found that siblings... |
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- Original Article
- TNF-α stimulated IL-8 and IL-10 expression in monocytes from patients with chronic granulomatous disease
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Kyung-Sue Shin
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Clin Exp Pediatr. 2008;51(10):1096-1101. Published online October 15, 2008
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Purpose : Patients with chronic granulomatous disease (CGD) have genetic mutations in a component of the NADPH oxidase enzyme that is necessary for the generation of the superoxide anion. The profound defect in innate immunity is reflected by the patients susceptibility to catalase-positive bacteria and fungi. In addition, CGD patients display signs of persistent inflammation, which is not associated only... |
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